Work

A perspective on malignancy in the marrow

Year: 2017

Type: article

Abstract: Malignancies that grow in the bone marrow cause a cascade of devastating consequences and are almost always fatal. For researchers to make significant headway in finding cures and treatments for these tumors and the subsequent devastation of cancer-induced bone disease, novel strategies and creative solutions will have to be considered. Great progress has been made in treating hematologic and sold tumor malignancies that ultimately affect the bone marrow, although it is also obvious that multi-disciplinary teams are required to ultimately win the war on cancers that affect the bone. In this perspective, we review recent advances in the identification of molecular and cellular targets in the bone marrow niche.

Source: Journal of Cellular Physiology

DOI: 10.1002/jcp.25860

Authors: Michaela R. Reagan, Jane B. Lian, Clifford J. Rosen, Gary S. Stein

Institutions: Tufts University, Maine Medical Center Research Institute, University of Maine, University of Vermont, University of Vermont Medical Center

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Maine Medical Center Research Institute, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases