Work

Post-Allogeneic Stem Cell Transplantation Maintenance Dasatinib in Philadelphia Chromosome Positive Acute Leukemia

Year: 2017

Type: article

Abstract: Introduction: The Philadelphia (Ph) chromosome is a common cytogenetic abnormality in Acute Lymphoblastic Leukemia (ALL) and Acute Leukemias of Ambiguous Lineage (ALAL). It is a poor prognostic factor, thus recommendations are for allogeneic hematopoietic stem cell transplantation (HSCT) in the first complete remission (CR). Use of tyrosine kinase inhibitors (TKIs) with chemotherapy in initial treatment of Ph+ acute leukemia is well established. Their role in post-transplant maintenance is not well defined.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2016.12.201

Authors: Keri Renee Maher, Ali McBride, Akshay Amaraneni, Onyemaechi Okolo, Sarmad Riaz Farooqui, Faiz Anwer

Institutions: University of Arizona, Barnes-Jewish Hospital

Language: English

Topic: Chronic Myeloid Leukemia Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650