Thrombotic Microangiopathy Can Occur Before Transplant in Children with HLH
Year: 2017
Type: article
Abstract: Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome of excessive immune activation, characterized by signs and symptoms of extreme inflammation, largely driven by interferon γ and other pro-inflammatory cytokines. Diagnostic criteria for HLH include either a molecular HLH diagnosis or five of the following eight criteria: fever, splenomegaly, cytopenias, hypertriglyceridemia and/or hypofibrinogenemia, hemophagocytosis, low or absent NK cell activity, elevated ferritin, and elevated sIL-2 receptor (sIL2R).
Institution: Cincinnati Children's Hospital Medical Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2589698748