Novel Genetic Variants Associated with Death Due to Acute Lymphoblastic Leukemia Within One Year after HLA-Matched Unrelated Donor Blood and Marrow Transplantation (DISCOVeRY-BMT Study)
Year: 2017
Type: article
Study design: Observational Study
Abstract: Disease relapse is the most common cause of early mortality after HLA-matched unrelated donor (URD) BMT. We performed a genome-wide association study (GWAS) named DISCOVeRY-BMT of survival outcomes in 3532 patients treated for AML, ALL or MDS, reported to CIBMTR from 2000-2011 and their 8/8 HLA-matched URDs (details previously published via ASH 2015, Tandem BMT meeting 2016). We now report outcomes for 577 ALL patients: Cohort 1 included 483 ALL recipients and their 466 HLA matched URDs, Cohort 2 included 94 recipients and 92 URDs of European-American (EA) ancestry typed at 637,655 markers and ~9 million imputed SNPs.
Authors: Theresa E. Hahn, Leah Preus, Philip L. McCarthy, Marcelo C. Pasquini, Kenan Onel, Xiaochun Zhu, Stephen Spellman, Christoper A. Haiman, Daniel O. Stram, Loreall Pooler, Xin Sheng, Qianqian Zhu, Li Yan, Qian Liu, Qiang Hu, Alyssa Clay, Sebastiano Battaglia, David Tritchler, Song Liu, Lara Sucheston-Campbell
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2590239953