Year: 2016
Type: dissertation
Abstract: Unlike the autosomes and X-chromosome, the Y-chromosome does not recombine with a homologous partner, save obligatory recombination with the X-chromosome in the pseudoautosomal regions.Because of the lack of recombination, the male-specific region of the Y is inherited clonally from father to son.This inheritance pattern influences the way the Ychromosome can be used forensically and in public health genetics.Chapter 1 of this dissertation details the history and use of the Y-chromosome in forensic genetics.The second half of the chapter examines the properties of a new estimator of population-specific FST on the Y-chromosome and its use in calculating the forensic match probability, as well as a comparison of the kappa method and an evolutionary model for match probability calculation.The Ychromosome has recently been used for forensic familial searching using a commercial DNA database.Chapter 2 presents a policy analysis of forensic familial searching in commercial DNA databases.Due to its small size and a number of analytic challenges, the Y-chromosome has largely been ignored in genetic association studies.One of the major analytic challenges is how to adjust for population stratification on the Y-chromosome, as relatedness is different between the Y and autosomes.Chapter 3 examines associations between SNPs on the Y-chromosome and obesity in Hispanic men, adjusting for autosomal and Y-chromosome principal components.v
Author: Taryn O. Hall
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2590247897