A Pilot Study of a Sequential Regimen of Intensive Chemotherapy (Bendamustine-Bridge) Followed by Autologous or Allogeneic Transplantation for Refractory Lymphomas
Year: 2017
Type: article
Study design: Clinical Trial
Abstract: Background: Patients with refractory or recurrent aggressive NHL and HL who fail to clear disease activity on PET after salvage chemotherapy have a high rate of recurrence after stem cell transplant (SCT). For such patients we used a sequential dose-intensification of (1) High dose bendamustine (200 mg/m2/day) × 2 followed by (2)R-BEAM conditioning with auto or allo SCT within14 days ± 5 days from bendamustine. Auto was used for those with PR to prior salvage defined as: PET SUV ≤8 and >50% decrease in tumor size. Allo SCT was used for those with
Authors: Tsiporah B. Shore, Yuliya Jhanwar, Maria Baldo, Edwidge Cuvilly, Richard Furman, Usama Gergis, June Greenberg, Danielle Guarneri, Jing-Mei Hsu, John Leonard, Tomer M. Mark, Kathleen Maignan, Peter Martin, Sebastian Mayer, Ruben Niesvizky, Adomah Opong, Roger Pearse, Adrienne Phillips, Adriana Rossi, Lisa Giulino-Roth, Jia Ruan, Sarah Rutherford, Jessy Ryan, Grace Suhu, Koen van Besien
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2590380825