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Myeloablative Flu/Bu Conditioning Provides Similar Overall Survival and Lower Non-Relapse Mortality Compared to Traditional Bu/Cy or Cy/TBI in Allogeneic Transplantation

Year: 2017

Type: article

Abstract: Myeloablative conditioning (MAC) is used in allogeneic hematopoietic stem-cell transplantation (HSCT) to maximize disease control. Common regimens include cyclophosphamide/busulfan (BuCy) and cyclophosphamide with total body irradiation (CyTBI). A non-randomized prospective CIBMTR study showed that overall survival (OS) was marginally better with Bu-based rather than TBI-based regimens. However, an EBMT retrospective registry analysis showed similar leukemia free survival using CyBuor CyTBI, while acute and chronic graft-versus-host-disease (GVHD) were greater in the TBI arm.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2016.12.177