Work

Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis

Year: 2017

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair‐associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta‐analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.

Source: Annals of Clinical and Translational Neurology

DOI: 10.1002/acn3.381

Authors: Xiqun Chen, Danielle Feng, Michael A. Schwarzschild, Xiang Gao

Institutions: Tongji University, Harvard University, Massachusetts General Hospital, Pennsylvania State University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,100