Functional Genetic Variants on 14Q32 Associate with Death Due to Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Within One Year after HLA-Matched Unrelated Donor Blood and Marrow Transplantation (DISCOVeRY-BMT Study)
Year: 2017
Type: article
Study design: Observational Study
Abstract: The most frequent cause of death after BMT is disease. To assess the contribution of genetics to survival outcomes we measured the association of variants typed on the Illumina HumanOmniExpress-24 Chip and 1-year survival in 3,532 AML, ALL or MDS patients reported to CIBMTR from 2000-2011 and their 8/8 HLA-matched URDs (DISCOVeRY-BMT cohorts). After quality control and imputation, almost 9 million typed and imputed SNPs were available on donor-recipient pairs in cohorts 1 (N = 2,111) and 2 (N = 779).
Authors: Lara Sucheston-Campbell, Leah Preus, Philip L. McCarthy, Marcelo C. Pasquini, Kenan Onel, Xiaochun Zhu, Stephen Spellman, Christoper A. Haiman, Daniel O. Stram, Loreall Pooler, Xin Sheng, Qianqian Zhu, Li Yan, Qian Liu, Qiang Hu, Alyssa Clay, Sebastiano Battaglia, David Tritchler, Song Liu, Theresa E. Hahn
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2591287247