Work

Selective Alloreactive Depletion Is Not a Mechanism Underlying the Efficacy of Post-Transplantation Cyclophosphamide in a Murine Haploidentical Transplantation Model

Year: 2017

Type: article

Abstract: Despite its clinical efficacy, the mechanisms by which post-transplantation cyclophosphamide (PTCy) prevents graft-versus-host disease (GVHD) remain poorly understood. The prevailing theory, extrapolated from murine skin allografting models, posits that PTCy preferentially eliminates alloreactive T cells, which may selectively proliferate early post-transplant. Those studies, which exploited strain-specific differential expression of certain T-cell receptor (TCR) Vβs as markers of alloreactive cells, also proposed two other mechanisms underlying PTCy's efficacy: intrathymic clonal deletion of alloreactive T cells and generation of suppressor T cells.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2016.12.332

Authors: Lucas P. Wachsmuth, Michael Eckhaus, Ehydel Castro, Ronald E. Gress, Christopher G. Kanakry

Institutions: National Institutes of Health, National Cancer Institute, Office of the Director, Office of Research Services

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650