Work

Conducting the finale of DNA replication

Year: 2017

Type: preprint

Abstract: Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and contribute to tumorigenesis and aging. In this issue of Genes & Development, Dewar and colleagues (pp. 275–290) identified an E3 ubiquitin ligase, CUL2LRR2, that modifies a subunit of the replicative CMG (Cdc45, minichromosome maintenance [MCM] subunits 2–7, and the GINS complex) helicase and triggers disassembly of the replication machinery. Their study offers critical insight into the mechanism of DNA replication termination while at the same time raising important questions for future research.

Source: Genes & Development

DOI: 10.1101/gad.297184.117

Authors: David Akopian, Michael Rape

Institutions: Howard Hughes Medical Institute, University of California, Berkeley

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: Medical Research Council

Award: G6294510760