The 33.1 kDa Excretory/secretory Protein Produced by Toxocara canis Larvae Serves as a Potential Common Biomarker for Serodiagnosis of Toxocariasis in Paratenic Animals and Human.
Year: 2017
Type: article
Abstract: BACKGROUND: which parasitise Canidae and Felidae respectively. In paratenic hosts, larvae of these worms cause multiple organ damage. However, how these paratenic hosts response to these worms and whether any common biomarker can be applied for diagnosis are still unclear. METHODS: spp. larvae to the worm's E/S antigens in different infected hosts including mice, rabbits and human, were examined. RESULTS: spp. resulting in distinct heterogenous WB band patterns. Mice and rabbits both responded to a 33.1 kDa E/S constituent that turned out to be the most sensitive protein for serodiagnosis. Sera from human toxocariasis patients showed heterogenous WB band patterns similar to those observed in rabbits and all responded to the 33.1 kDa band. CONCLUSION: 33.1 kDa E/S protein can be considered as a critical common biomarker for toxocariasis immuno-diagnosis in both paratenic animals and human and its specificity requires further investigation.
Source: PubMed Central
Authors: Huu-Hung Nguyen, Doan-Trung Vo, Thi-Tuyet-Trinh Thai, Thi-Thanh-Thao LE, Thanh-Dong LE, Nghia-Son Hoang
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2592539050