Year: 2017
Type: article
Study design: Observational Study
Abstract: Matrix metalloproteinases (MMPs), which degrade extracellular proteins as part of a variety of physiological processes, and their inhibitors have been implicated in the dental caries process. Here we investigated 28 genetic variants spanning theMMP10,MMP14, andMMP16genes to detect association with dental caries experience in 13 age- and race-stratified ( n=3,587 ) samples from 6 parent studies. Analyses were performed separately for each sample, and results were combined across samples by meta-analysis. Two SNPs (rs2046315 and rs10429371) upstream ofMMP16were significantly associated with caries in an individual sample of white adults and via meta-analysis across 8 adult samples after gene-wise adjustment for multiple comparisons. Noteworthy is SNP rs2046315 ( p=8.14×10-8 ) association with caries in white adults. This SNP was originally nominated in a genome-wide-association study (GWAS) of dental caries in a sample of white adults and yielded associations in a subsequent GWAS of surface level caries in white adults as well. Therefore, in our study, we were able to recapture the association between rs2046315 and dental caries in white adults. Although we did not strengthen evidence thatMMPs 10,14, and16influence caries risk,MMP16is still a likely candidate gene to pursue.
DOI: 10.1155/2017/8465125
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,560
Funders: Commonwealth of Pennsylvania, National Science Foundation, U.S. Department of Defense, Pennsylvania Department of Health, University of Pittsburgh, National Institutes of Health, School of Dental Medicine, University of Pittsburgh, National Institute on Drug Abuse, National Institute of Dental and Craniofacial Research
Awards: G1342832497, G1489376469, Longitudinal Study of Fluoride, Diet, Caries & Fluorosis, Fluoride & Other Factors in Childhood and Adolescent Bone Development, G2724527233, Modeling childhood dental caries patterns for genomic and epigenetic analysis, G3539819305, Dental Caries: Whole Genome Association and Gene x Environment Studies, G3914107730, Drug Abuse Vulnerability: Mechanisms and Manifestations, G423601829, Substance Use Disorder Liability: Candidate Gene System, Factors Contributing to Oral Health Disparities in Appalachia, G4407346161, G4905309547, G4964566539, G5436171093, G6064507860, G632409923, G6358880520, G6536674355, G6845061904, G7030792379, G710930085, G7196225898, G7209704103, G7573442051, Training and Experimentation in Computational Biology (TECBio), Genetics of Caries, G836833792, G8405951238
OpenAlex ID: W2593243297