Work

Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase

Year: 2017

Type: article

Abstract: genes), overexpression of GyrA, GyrB, or GyrA and GyrB together does not suppress the inhibitory effect of the gyramides. These observations support the hypothesis that the gyramides inhibit DNA gyrase using a mechanism that is unique from other known inhibitors.

Source: MedChemComm

DOI: 10.1039/c7md00012j

Authors: Katherine A. Hurley, Thiago M. A. Santos, Molly R. Fensterwald, Madhusudan Rajendran, Jared T. Moore, Edward I. Balmond, Brice J. Blahnik, Katherine C. Faulkner, Marie H. Foss, Victoria A. Heinrich, Matthew G. Lammers, Lucas C. Moore, Gregory D. Reynolds, Galen P. Shearn-Nance, Brian A. Stearns, Zi W. Yao, Jared T. Shaw, Douglas B. Weibel

Institutions: University of Wisconsin–Madison, University of California, Davis

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Award: Revisiting the bacterial cell wall as a target for new antibiotics

OpenAlex ID: W2593539445

FWCI: 0.185

Cites: 42

Cited by: 10

Related to: 10