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Proton Magnetic Resonance Spectroscopy Indicates Preserved Cerebral Biochemical Composition in Duchenne Muscular Dystrophy Patients

Year: 2017

Type: article

Abstract: BACKGROUND: Duchenne muscular dystrophy (DMD) is caused by the absence of dystrophin. DMD is associated with specific learning and behavioural disabilities. In the brain, dystrophin is associated with GABAA receptors and aquaporin-4 in neurons and astrocytes, respectively, but little is known about its function. OBJECTIVE AND METHODS: In this study we aimed to compare the biochemical composition between patients and healthy controls in brain regions that are naturally rich in dystrophin using magnetic resonance spectroscopy. Given previous conflicting results obtained at clinical field strengths, we obtained data using a 7 Tesla system with associated higher signal-to-noise ratio and spectral resolution. RESULTS: Results indicated unchanged biochemical composition in all regions investigated, and increased variance in glutamate in the frontal cortex.

Source: Journal of Neuromuscular Diseases

DOI: 10.3233/jnd-160201

Authors: Nathalie Doorenweerd, Melissa Hooijmans, Stephanie A. Schubert, Andrew G. Webb, Chiara S.M. Straathof, Erik W. van Zwet, Mark A. van Buchem, Jan J.G.M. Verschuuren, Jos G.M. Hendriksen, Erik H. Niks, Hermien E. Kan

Institutions: Leiden University, Leiden University Medical Center, Maastricht University Medical Centre, Kempenhaeghe

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2593551254

FWCI: 0.629

Cites: 34

Cited by: 8

Related to: 10