Year: 2017
Type: book-chapter
Abstract: The prion hypothesis, once a heretical violation of the central dogma of molecular biology, has become an accepted mechanism used to explain a host of progressive neurodegenerative diseases in mammals and heritable phenotypes in yeast. From the beginning, mathematical models have been an essential tool in studying prion and other protein misfolding/aggregation processes. In this work, we review some of the major mathematical studies that have contributed to our understanding of prion disease and discuss trends in current and future studies.
Source: InTech eBooks
DOI: 10.5772/66917
Author: Suzanne S. Sindi
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2593749219