Work

ZNF50 3/ Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression

Year: 2017

Type: article

Abstract: Significance Transcription factor GATA3 has emerged as one of top three altered genes in mammary tumors. In breast cancer, GATA3 expression has been associated with an estrogen receptor (ER)-positive (ER + /luminal) phenotype. ER + tumor cells resemble more differentiated cells, and affected patients are more responsive to therapy and have overall better survival outcomes. Loss of GATA3 correlates with ER − , less differentiated, and more aggressive tumors with poorer prognosis. We have identified zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional repressor that down-regulates GATA3 and promotes aggressive breast cancer. Thus, ZPO2 could be an important oncogenic target for prediction of aggressive breast cancer.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1701690114