A Meta-analytic Review of Selected Adverse Drug Events (ADEs) of Long-term Prescription Opioids for Chronic Non-cancer Pain (CNCP)
Year: 2016
Type: dissertation
Abstract: Background: Opioids are considered one of the most effective analgesics. However, knowledge on opioid adverse drug events (ADEs) is limited and the current state of the literature has remained elusive. Purpose: This meta-analytic review focused on five selected adverse drug events (SADEs) (misuse, abuse, addiction, overdose, and death) of prescription opioids to surmise the overall state of this literature and evaluate quality of reporting and risk of bias. Methods: Studies were acquired from research databases, including: MEDLINE, EMBASE, CINAHL, PsycINFO, CENTRAL, and Business Source Premier. Results: Ninety studies satisfied inclusion and exclusion criteria and were included. Quality of reporting of SADEs, determined via McHarm, risk of bias, assessed using a Cochrane guideline, and overall event rates of SADEs are reported. Conclusion: Results revealed that quality of reporting was poor and risk of bias was high. Findings suggest that quality of reporting of SADEs and risk of bias must be improved.
Source: TSpace (University of Toronto)
Author: Matthew Jason Pelcowitz
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2594407950