Work

A Biocatalytic Route to Highly Enantioenriched β‐Hydroxydioxinones

Year: 2017

Type: article

Abstract: A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in β-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. We have demonstrated both a wide substrate scope and a high degree of scalability.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.201700095

Authors: Rick C. Betori, Eric R. Miller, Karl A. Scheidt

Institution: Northwestern University

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Chemistry of Life Processes Predoctoral Training Program