Work

Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation

Year: 2017

Type: conference-paper

Abstract: Optical phase conjugation (OPC) based wavefront shaping techniques focus light through or within scattering media, which is critically important for deep-tissue optical imaging, manipulation, and therapy. However, to date, the sample thicknesses used in wavefront shaping experiments have been limited to only a few millimeters or several transport mean free paths. Here, by using a long-coherence-length laser and an optimized digital OPC system that efficiently delivers light power, we focused 532 nm light through tissue-mimicking phantoms up to 9.6 cm thick, as well as through ex vivo chicken breast tissue up to 2.5 cm thick.

Source: Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI: 10.1117/12.2251052

Authors: Yuecheng Shen, Yan Liu, Cheng Ma, Lihong V. Wang

Institutions: California Institute of Technology, Washington University in St. Louis

Language: English

Topic: Random lasers and scattering media

Subfield: Acoustics and Ultrasonics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Photon tunneling: Shedding new light on biomedicine, In vivo imaging of single circulating cells