Assessing the Performance of 3 Human Immunodeficiency Virus Incidence Risk Scores in a Cohort of Black and White Men Who Have Sex With Men in the South
Year: 2017
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Risk scores have been developed to identify men at high risk of human immunodeficiency virus (HIV) seroconversion. These scores can be used to more efficiently allocate public health prevention resources, such as pre-exposure prophylaxis. However, the published scores were developed with data sets that comprise predominantly white men who have sex with men (MSM) collected several years prior and recruited from a limited geographic area. Thus, it is unclear how well these scores perform in men of different races or ethnicities or men in different geographic regions. METHODS: We assessed the predictive ability of 3 published scores to predict HIV seroconversion in a cohort of black and white MSM in Atlanta, GA. Questionnaire data from the baseline study visit were used to derive individual scores for each participant. We assessed the discriminatory ability of each risk score to predict HIV seroconversion over 2 years of follow-up. RESULTS: The predictive ability of each score was low among all MSM and lower among black men compared to white men. Each score had lower sensitivity to predict seroconversion among black MSM compared to white MSM and low area under the curve values for the receiver operating characteristic curve indicating poor discriminatory ability. CONCLUSIONS: Reliance on the currently available risk scores will result in misclassification of high proportions of MSM, especially black MSM, in terms of HIV risk, leading to missed opportunities for HIV prevention services.
Source: Sexually Transmitted Diseases
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Understanding substance use and incident HIV/STI among young black MSM, Translational Methamphetamine AIDS Research Center (TMARC), G2650613164, Primary Infection Resource Consortium (PIRC), Explaining Differences in HIV Prevalence and Incidence in Black and White MSM, Efficacy of ART to Interrupt HIV Transmission Networks, Delay Discounting and HIV Sexual Risk Behavior in Men who Have Sex with Men, Interdisciplinary Research Fellowship in NeuroAIDS
OpenAlex ID: W2594926730