Year: 2010
Type: article
Abstract: Obesity is a problem affecting people around much of the world.Intake of soy may decrease tissue lipid accumulation and adipose tissue mass.We aimed to determine the effect of fermented soy product on weight gain and adiposity in growing male C57Bl/6 mice.Eight week old mice were put in a Casein diet, Soy diet, or Fermented Soy diet (FSoy) group for 17 weeks.Half of the mice fed the Casein diet were switched to the FSoy diet at 8 weeks (CtoFSoy).The FSoy reduced weight gain and adiposity compared to the Soy diet and the Casein diet.At 16 weeks, fasting glucose from the FSoy was significantly lower than the Casein diet or Soy diet.In an insulin tolerance test (ITT), glucose lowering was more dramatic from the FSoy compared to the Soy or Casein diet.Fasting insulin was significantly lower in the FSoy and Soy diet compared to the Casein, and the FSoy group was significantly lower than the Soy group.Serum leptin was significantly reduced from the FSoy and Soy diet compared to the Casein diet.The FSoy diet peroxisome proliferator activated receptor gamma (PPAR-γ) mRNA was significantly lowered compared to the Soy diet.FSoy reduced adipose mass, plasma insulin and glucose, serum leptin, insulin tolerance, and adipose tissue responses in fatty acid-binding protein-4 (FABP4), hormonesensitive lipase (HSL) and F4/80 gene transcription.These data suggest that the beneficial weight and insulin responsiveness observed in the C57Bl/6 mice from the FSoy study diet are largely due to PPAR-γ-independent mechanisms, and may, in part, be due to PPAR-α-dependent mechanisms.iii DEDICATION This thesis is dedicated to my baby (boy or girl).Thank you for being so cooperative during this writing process.I am looking forward to meeting you soon.mentor during all of my years at Ohio
Author: Gayle E. Shrode
Institution: The Ohio State University
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
Funder: Ohio State University
OpenAlex ID: W2595020625