Work

Signatures of DNA target selectivity by ETS transcription factors

Year: 2017

Type: review

Abstract: The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. DNA target specificity derives from combinatorial interactions with other proteins as well as intrinsic heterogeneity among ETS domains. Emerging evidence suggests molecular hydration as a fundamental feature that defines the intrinsic heterogeneity in DNA target selection and susceptibility to epigenetic DNA modification. This perspective invokes novel hypotheses in the regulation of ETS proteins in physiologic osmotic stress, their pioneering potential in heterochromatin, and the effects of passive and pharmacologic DNA demethylation on ETS regulation.

Source: Transcription

DOI: 10.1080/21541264.2017.1302901

Authors: Gregory M. K. Poon, Hye Mi Kim

Institution: Georgia State University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, University of Missouri, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: Direct activation of hematopoietic transcription factors, G1658465232, G1832048361