Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features
Year: 2017
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: The prognostic value of reduced NM23 expression for gastric cancer (GC) patients is still contradictory. Thus, we conducted a meta-analysis to quantitatively evaluate the association of NM23 expression with GC risk and clinical features by analyzing 27 publications. The result of our meta-analysis indicated that NM23 expression is markedly reduced in gastric cancer tissues (OR = 3.15; 95% CI = 1.97–5.03; P<0.001 ). Furthermore, NM23 expression was negatively correlated with N stage, TNM stage, and histological grade. However, NM23 expression was not correlated with T stage, lymphatic invasion, vascular invasion, and 5-year overall survival rate. In conclusion, reduced NM23 expression correlated with gastric cancer risk, but its association with GC clinical features remains inconclusive. Therefore, large-scale and well-designed studies, which use uniform antibody and criterion of NM23 positive expression, are required to further validate the role of the NM23 in predicting GC progression.
Source: BioMed Research International
DOI: 10.1155/2017/8047183
Authors: Min Fang, Yifeng Tao, Zhimin Liu, Hao Huang, Min Lao, Lingsha Huang, Bo Zhu
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
OpenAlex ID: W2595487237