Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart
Year: 2017
Type: article
Abstract: Ischaemic heart disease and the heart failure that often results, remain the leading causes of death and disability in Europe and worldwide. As such, in order to prevent heart failure and improve clinical outcomes in patients presenting with an acute ST-segment elevation myocardial infarction and patients undergoing coronary artery bypass graft surgery, novel therapies are required to protect the heart against the detrimental effects of acute ischaemia/reperfusion injury (IRI). During the last three decades, a wide variety of ischaemic conditioning strategies and pharmacological treatments have been tested in the clinic-however, their translation from experimental to clinical studies for improving patient outcomes has been both challenging and disappointing. Therefore, in this Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart, we critically analyse the current state of ischaemic conditioning in both the experimental and clinical settings, provide recommendations for improving its translation into the clinical setting, and highlight novel therapeutic targets and new treatment strategies for reducing acute myocardial IRI.
Source: Cardiovascular Research
DOI: 10.1093/cvr/cvx049
Authors: Derek J. Hausenloy, David Garcia-Dorado, Hans Erik Bøtker, Sean M. Davidson, James Downey, Felix B. Engel, Robert Jennings, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Michel Ovize, Cinzia Perrino, Fabrice Prunier, Rainer Schulz, Joost P.G. Sluijter, Linda W. Van Laake, Jakob Vinten-Johansen, Derek M. Yellon, Kirsti Ytrehus, Gerd Heusch, Péter Ferdinandy
Institutions: St Bartholomew's Hospital, National University of Singapore, Duke-NUS Medical School, UCL Biomedical Research Centre, National Heart Centre Singapore, University College London, Universitat Autònoma de Barcelona, Vall d'Hebron Hospital Universitari, Aarhus University Hospital, University of South Alabama, Friedrich-Alexander-Universität Erlangen-Nürnberg, Duke University, South African Medical Research Council, University of Cape Town, Tel Aviv University, Sheba Medical Center, University of Chieti-Pescara, Lyon 1 Université, Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition, Hôpital Louis Pradel, Federico II University Hospital, University of Naples Federico II, Centre Hospitalier Universitaire d'Angers, Université d'Angers, Justus-Liebig-Universität Gießen, University Medical Center Utrecht, Emory University, UiT The Arctic University of Norway, Essen University Hospital, West German Heart and Vascular Center Essen, Semmelweis University, Pharmahungary Group (Hungary)
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: National Institute for Health and Care Research, British Heart Foundation, University College London, Rosetrees Trust, European Society of Cardiology, European Cooperation in Science and Technology, European Foundation for the Study of Diabetes, Deutsche Forschungsgemeinschaft, Ministero della Salute, Hungarian Scientific Research Fund, European Association for the Study of Diabetes, Novo Nordisk Fonden, Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, Medical Research Council, Instituto de Salud Carlos III
Awards: G1121758838, G1755966364, G1801855840, G274252275, G3106377081, G3310720718, G3559709381, G36238222, G4173566781, Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention (ERIC-PPCI): a multi-centre randomised controlled clinical study, G4503534332, G471312740, G4783766304, G5418797795, G5532691452, G5786934800, G6231849770, G6649169425, G6739505752, G7115774498, G7158856516, G7300967583, G73078175, Terapia combinada con condicionamiento isquémico remoto y tratamiento metabólico para la prevención del daño por reperfusión en el infarto de miocardio. Eficacia en pacientes diabéticos, G7739847915, G80800696, G8174345170, Mitochondrial morphology and the mitochondrial permeability transition pore as targets for cardioprotection
OpenAlex ID: W2595585904