Work

Anti-oxidative Approaches to Improve Neuronal Viability Surrounding Implanted Intracortical Microelectrodes

Year: 2014

Type: article

Abstract: Intracortical microelectrodes show large potential in helping neuroscientists further map and understand the mechanics of the brain.In addition, microelectrode technology could potentially provide the means for translating "thought" into "movement" for patients suffering from neurological deficits.However, general unreliability of microelectrode technology has halted its widespread clinical use.Further understanding neuronal viability around implanted microelectrodes, in comparison to controls, up to four months post-implantation.The results of this work further support the hypothesis that oxidative stress may facilitate the propagation of biological-mediated failure modes to intracortical microelectrodes.We anticipate that anti-oxidative approaches outlined here will be directly translational and aide in the improved reliability of microelectrode technology for use in both basic neuroscience and clinical applications.

Source: OhioLink ETD Center (Ohio Library and Information Network)

Author: Kelsey A. Potter

Institution: Case Western Reserve University

Language: English

Topic: Neuroscience and Neural Engineering

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, Case Western Reserve University

OpenAlex ID: W2595656527

FWCI:

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Related to: 10