Year: 2011
Type: article
Abstract: Heterogeneous oxygen distribution in tumor microenvironment can contribute to therapy failure.Anoxia and severe hypoxia in microregions of solid tumors results in decreased activity of cells or up-regulation of hypoxia linked cell survival mechanisms.These adaptations are in favor of survival and proliferation of hypoxic cells in adverse conditions making them resistant to therapy.Knowledge of oxygen distribution inside tumor biopsies and models along with therapeutic efficacy of drug molecules would be of great value to improve clinical outcomes by personalizing therapy and and in-vitro screening of potential new drug molecules.Current methodologies for oxygen measurement in 3D tissues, based on both optical and electrochemical principles, are restricted to single time point measurements assuming steady state oxygen distributions.Both time-and depth-resolved continuous mapping of oxygen inside tumor tissue models has not been achieved. References
Author: Disha Sheth
Institution: Case Western Reserve University
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funder: Case Western Reserve University
OpenAlex ID: W2595680288