Year: 2017
Type: article
Abstract: Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.
Source: Aging Cell
DOI: 10.1111/acel.12585
Authors: Diogo Barardo, Daniel Thornton, Harikrishnan Thoppil, Michael Walsh, Samim Sharifi, Susana Ferreira, Andreja Anžič, Maria Fernandes, Patrick Monteiro, Tjaša Grum, Rui Cordeiro, Evandro Araújo De-Souza, Arie Budovsky, Natali Araujo, Jan Gruber, Michael Petrascheck, Vadim E. Fraifeld, Alexander Zhavoronkov, Alexey Moskalev, João Pedro de Magalhães
Institutions: University of Liverpool, Amrita Vishwa Vidyapeetham, ETH Zurich, Universidade Federal de São Paulo, Ben-Gurion University of the Negev, National University of Singapore, Yale-NUS College, Scripps Research Institute, Johns Hopkins University, Insilico Medicine (United States), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow Institute of Physics and Technology, Institute of Biology of Komi Scientific Centre
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,697
Funder: Wellcome Trust
OpenAlex ID: W2595793016