Platelets Cellular and Functional Characteristics in Patients with Atrial Fibrillation: A Comprehensive Meta-Analysis and Systematic Review
Year: 2017
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: BACKGROUND This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of platelet cellular and functional characteristics including platelet count (PC), MPV, platelet distribution width (PDW), platelet factor 4, beta thromboglobulin (BTG), and p-selectin with the occurrence of atrial fibrillation (AF) and consequent stroke. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating platelet characteristics in patients with paroxysmal, persistent and permanent atrial fibrillations. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS Literature search of all major databases retrieved 1,676 studies. After screening, a total of 73 studies were identified. Pooled analysis showed significant differences in PC (weighted mean difference (WMD)=-26.93 and p<0.001), MPV (WMD=0.61 and p<0.001), PDW (WMD=-0.22 and p=0.002), BTG (WMD=24.69 and p<0.001), PF4 (WMD=4.59 and p<0.001), and p-selectin (WMD=4.90 and p<0.001). CONCLUSIONS Platelets play a critical and precipitating role in the occurrence of AF. Whereas distribution width of platelets as well as factors of platelet activity was significantly greater in AF patients compared to SR patients, platelet count was significantly lower in AF patients.
Authors: Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Anton Sabashnikov, Aron-Frederik Popov, Seyed Jalil Mirhosseini, Luis Nombela-Franco, Luca Testa, Mohammadreza Lotfaliani, Mohamed Zeriouh, Tong Liu, Hamidreza Dehghan, Senol Yavuz, Michel Pompeu Barros de Oliveira Sá, William L. Baker, Jae-Sik Jang, Mengqi Gong, Umberto Benedetto, Pascal M. Dohmen, Fabrizio D\'Ascenzo, Abhishek J. Deshmukh, Giuseppe Biondi-Zoccai, Hugh Calkins, Gregg W. Stone, Integrated Meta-Analysis of Cardiac Surgery and Cardiology-Group [IMCSC-Group]
Institutions: Carl von Ossietzky Universität Oldenburg, Shahid Sadoughi University of Medical Sciences and Health Services, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Hospital Clínico San Carlos, IRCCS Policlinico San Donato, Second Hospital of Tianjin Medical University, Tianjin Medical University, S.B.Ü. Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Hartford Hospital, University of Connecticut, Inje University, Inje University Busan Paik Hospital, University of Bristol, University of Turin, Mayo Clinic, Sapienza University of Rome, Johns Hopkins University, Johns Hopkins Medicine, NewYork–Presbyterian Hospital, Columbia University Irving Medical Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2595831951