Year: 2010
Type: article
Abstract: The heart is the most metabolically active organ.Several prevalent cardiac diseases, such as heart failure, ischemic and diabetic cardiomyopathy, are associated with abnormal energy metabolism.However, due to the lack of nondestructive methods to quantify metabolic activities and mitochondrial function, an integrative understanding of the mechanisms underlying metabolic dysfunction in diseased heart has been incomplete.Therefore, in the current thesis, we aimed at developing a novel approach that combines magnetic resonance spectroscopy (MRS) technique with system biology for quatitative understanding of metabolic communication between subcellular compartments and mitochondrial function in intact hearts.A comprehensive multi-domain model of cardiac metabolism that encompasses the malate-aspartate (M-A) shuttle was developed to investigate the metabolic responses of cardiomyocytes to ischemia (Chapter 2).By functionally localizing the M-A shuttle in a subdomain within the cardiomyocytes, model simulations suggested that the decreased shuttle flux during ischemia was due to the redistribution of shuttle-associated
Author: Ming Lu
Institution: Case Western Reserve University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: Case Western Reserve University
OpenAlex ID: W2595875359