Wpływ hormonalnej terapii zastępczej na odstęp i dyspersję QT u kobiet po menopauzie z nadciśnieniem tętniczym
Year: 2002
Type: article
Abstract: The influence of hormone replacement therapy on the QT interval and the QT dispersion in postmenopausal hypertensive women Introduction: Electrocardiograms show that the QT interval, also the corrected one (QTc), is longer for female gender then for male gender.This is a negative feature since the longer QT interval and its greater dispersion (DQTc) increases the risk of death due to cardiovascular diseases.The study aimed at determining the influence of hormone replacement therapy (HRT) on the bioelectric activity of the myocardium, which is estimated on the basis of QTc and DQTc during an electrocardiographic exercise stress test in postmenopausal women suffering from primary hypertension. Material and methods:The subjects of the study were 50 postmenopausal women (average age 51.8 ± 4.6 years) with hypertension (average duration of 6.8 ± 4.7 years).30 women treated for hypertension received the HRT (17-b-estradiol and norethisterone acetate, TTS); the remaining 20 women were the control group, as they did not receive any hormonal treatment.An electrocardiographic exercise stress test was carried out before and after the hormonal treatment.In electrocardiograms were measured the QT interval and the corrected QT dispersion.Results: Both groups had identical QTc and DQTc at baseline.These values remained the same for both groups in the ECG at rest after one year of the treatment.An increase in the DQTc value was observed in both groups at the peak of exercise.However, it was greater for the HRT group.It was also observed that in this group systolic blood pressure at rest was significantly reduced from 137.7 ± 18.5 mm Hg before the treatment to 124.0 ± 16.5 mm Hg at year (p < 0.001).Conclusions: Annual, transdermal, combined HRT added to the standard treatment of hypertension increases the corrected QT dispersion at peak of exercise stress test in postmenopausal hypertensive women.(Folia Cardiol.2002; 9: 51-58) QT dispersion, hormone replacement therapy, hypertension
Language: Polish
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2596008888