Get started
Work

Corymbulosins D–H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Year: 2017
Type: article
Abstract: (1:1) extract of the bark of Laetia corymbulosa provided five new clerodane diterpenes with an isozuelanin skeleton, designated as corymbulosins D-H (1-5), as well as the known corymbulosins B (6) and C (7), for which the relative configurations were not previously determined. The structures of 1-5 were characterized on the basis of 1D and 2D NMR spectroscopic and HRMS analysis. The absolute configurations of all isolated compounds 1-7 were verified through chemical methods, including modified Mosher esterifications or oxidation of the hydroxy group at C-2, ECD experiments, and spectroscopic data comparison. The isolated compounds were evaluated for antiproliferative activity against a small panel of human cancer cell lines.
DOI: 10.1021/acs.jnatprod.6b01151
Authors: Airi Suzuki, Yohei Saito, Shuichi Fukuyoshi, Masuo Goto, Katsunori Miyake, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Institutions: Kanazawa University, University of North Carolina at Chapel Hill, Tokyo University of Pharmacy and Life Sciences, National Institutes of Health, China Medical University, China Medical University Hospital
Language: English
Open Access status: green
OpenAlex ID: W2596410047
FWCI: 0.679
Cites: 10
Cited by: 10
Related to: 10