Work

SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth

Year: 2017

Type: article

Abstract: , and a potent cytotoxin, auristatin F (AF). The conjugates selectively and potently inhibited proliferation of tumor cells expressing the target integrins. We anticipate that the small molecule-RIP bioconjugate approach can be broadly applied using other small molecule drugs.

Source: Chemical Communications

DOI: 10.1039/c7cc00745k

Authors: Saumya Roy, Jun Y. Axup, Jane S. Forsyth, Rajib K. Goswami, Benjamin M. Hutchins, Krishna M. Bajuri, Stephanie A. Kazane, Vaughn V. Smider, Brunhilde H. Felding, Subhash C. Sinha

Institution: Scripps Research Institute

Language: English

Topic: Toxin Mechanisms and Immunotoxins

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Awards: G2012733601, G3632953058, G531616620, G6657219455

OpenAlex ID: W2596469211

FWCI: 0.738

Cites: 24

Cited by: 7

Related to: 10