The Effect of Varying Levels of GH Treatment on the Body Composition of Obese and Diabetic Mice
Year: 2008
Type: article
Abstract: This study examined the effects of various doses of Growth Hormone (GH) on obesity and diabetes in mice.Male C57Bl/6J mice were either placed on a low-fat (LF) or high-fat (HF) diet at 3 weeks of age and maintained on that diet for 16 weeks.The HF group was divided into five injection groups and received either daily saline injections or increasing doses of bGH, while the LF group was injected with saline.Injections were performed daily for 6 weeks.Obese mice injected with the highest dose of GH (5 µg/g BW) had the greatest increase in lean mass and the greatest decrease in fat mass.Remarkably, these animals did not differ significantly from the LF saline-injected controls after 6 weeks of GH treatment and had virtually no change in overall body weight while continuing on a HF diet.Furthermore, the highest dose of GH improved blood glucose levels to near LF control levels, despite the known diabetogenic effect of GH, but was unable to return plasma insulin to control levels suggesting some level of insulin resistance.
Author: Amanda J. Palmer
Institution: Ohio University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2596489099