Body Size Indicators and Risk of Gallbladder Cancer: Pooled Analysis of Individual-Level Data from 19 Prospective Cohort Studies
Year: 2017
Type: article
Abstract: Background: There are few established risk factors for gallbladder cancer beyond gallstones. Recent studies suggest a higher risk with high body mass index (BMI), an indicator of general heaviness, but evidence from other body size measures is lacking. Methods: Associations of adult BMI, young adult BMI, height, adult weight gain, waist circumference (WC), waist–height ratio (WHtR), hip circumference (HC), and waist–hip ratio (WHR) with gallbladder cancer risk were evaluated. Individual-level data from 1,878,801 participants in 19 prospective cohort studies (14 studies had circumference measures) were harmonized and included in this analysis. Multivariable Cox proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI). Results: After enrollment, 567 gallbladder cancer cases were identified during 20.1 million person-years of observation, including 361 cases with WC measures. Higher adult BMI (per 5 kg/m2, HR: 1.24; 95% CI, 1.13–1.35), young adult BMI (per 5 kg/m2, HR: 1.12; 95% CI, 1.00–1.26), adult weight gain (per 5 kg, HR: 1.07; 95% CI, 1.02–1.12), height (per 5 cm, HR: 1.10; 95% CI, 1.03–1.17), WC (per 5 cm, HR: 1.09; 95% CI, 1.02–1.17), WHtR (per 0.1 unit, HR: 1.24; 95% CI, 1.00–1.54), and HC (per 5 cm, HR: 1.13; 95% CI, 1.04–1.22), but not WHR (per 0.1 unit, HR: 1.03; 95% CI, 0.87–1.22), were associated with higher risks of gallbladder cancer, and results did not differ meaningfully by sex or other demographic/lifestyle factors. Conclusions: These findings indicate that measures of overall and central excess body weight are associated with higher gallbladder cancer risks. Impact: Excess body weight is an important, and potentially preventable, gallbladder cancer risk factor. Cancer Epidemiol Biomarkers Prev; 26(4); 597–606. ©2017 AACR.
Authors: Peter T. Campbell, Christina C. Newton, Cari M. Kitahara, Alpa V. Patel, Patricia Hartge, Jill Koshiol, Katherine A. McGlynn, Hans-Olov Adami, Amy Berrington de González, Laura E. Beane Freeman, Leslie Bernstein, Julie E. Buring, Neal D. Freedman, Yu-Tang Gao, Graham G. Giles, Marc J. Gunter, Mazda Jenab, Linda M. Liao, Roger L. Milne, Kim Robien, Dale P. Sandler, Catherine Schairer, Howard D. Sesso, Xiao-Ou Shu, Elisabete Weiderpass, Alicja Wolk, Yong-Bing Xiang, Anne Zeleniuch-Jacquotte, Wei Zheng, Susan M. Gapstur
Institutions: American Cancer Society, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Harvard University, Karolinska Institutet, Beckman Research Institute, Brigham and Women's Hospital, Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute, The University of Melbourne, Cancer Council Victoria, Centre international de recherche sur le cancer, George Washington University, National Institutes of Health, National Institute of Environmental Health Sciences, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, New York University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Genetic And Environmental Risk Factors For Breast Cancer, G1734361364, G2176833112, G229684361, G2788466971, G2802736426, Cancer Risk Reduction and Diet: A Cohort Study of Women, G3426488059, G3652486217, Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention, G3850548428, The NYU Women's Health Study, Vitamin D, Related Genes and Breast Cancer Risk, G4522543292, G4582778782, Harvard Chan School NIEHS Center for Environmental Health, G5111245462, Physicians' Health Study II: Prevention Trial of Vitamins, The Women's Health Study: Addition of New Data to Maximize its Research Impact, TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'S, G6766166885, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, G718805128, Women's Health Study: Continued Follow-up, G814381192, G8554986239, G9000000306, G9000160301
OpenAlex ID: W2596497316