Year: 2017
Type: article
Abstract: : Dry eye and tear dysfunction are common ocular disorders that cause cornea barrier disruption resulting in a poorly lubricated and irregular cornea epithelium, eye irritation and blurred vision. Increased levels and activities of matrix metalloproteinases (MMPs), particularly MMP-9, have been detected in the tears and ocular surface epithelial and inflammatory cells in dry eye. MMPs have been found to participate in disruption of tight junctions in the apical cornea epithelium leading to their accelerated desquamation and barrier disruption. This review summarizes evidence showing the contribution of MMPs to dry eye pathogenesis and their roles as biomarkers and therapeutic targets. Keywords: matrix metalloproteinase, dry eye, keratitis sicca, cornea, barrier function, Sjögren syndrome
Source: Metalloproteinases In Medicine
DOI: 10.2147/mnm.s107246
Institution: Baylor College of Medicine
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: Baylor-UT Houston Center for AIDS Research, Pathogenesis of Conjunctival Squamous Metaplasia, Core Grant for Vision Research, G2307697538, BD Biosciences Special Order LSRII, Immunology Scientist Training Program, G4408882717, G5465708471, G5717416320, G5850682332, G9000240210, G9000276693, G9000286817, G9000331185, Baylor College of Medicine Cancer Center - Cancer Center Support Grant
OpenAlex ID: W2597003311