The Human Eye in Presbyopia: Changes in the Lens and Ciliary Body with Age and Accommodation
Year: 2011
Type: article
Study design: Observational Study
Abstract: Despite the ubiquitous nature of presbyopia, numerous questions remain in our understanding of the mechanism of this age-related decline in focusing ability.Previous research was limited by the inability to visualize the internal structures of the human eye in vivo.Studies have been confounded by the use of animal models not entirely similar to humans; pharmacological agents known to affect the normal physiological response; post mortem effects inherent to the use of cadaveric eyes; and ex vivo work using nonphysiological forces and discounting the role of the iris, vitreous, and choroid.The purpose of this dissertation was to objectively quantify changes in the lens and ciliary body of the human eye in vivo in a single cohort of patients, before, during and after onset of presbyopia.This was achieved through the development of optical coherence tomography and magnetic resonance imaging techniques and computer-based image segmentation programs.Ninety-two patients between the ages of 30 and 50 years were enrolled in the study.This dissertation reports the analysis of a subset of 26 emmetropic subjects.Regressions of ocular biometric data demonstrate the significant changes in lens shape and size with age.Multivariate mixed model analysis reveals the contributions of both the lens and ciliary body in accommodative function.
Author: Kathryn Richdale
Institution: The Ohio State University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2597168333