Work

Specific deletion of LKB1/ Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice

Year: 2017

Type: article

Abstract: Significance Symptoms of benign prostatic hyperplasia (BPH) affect many older men, but the etiology of the disease is largely unknown. We show that male mice develop prostatic stromal hyperplasia accompanied by lower urinary tract symptoms that appear similar to BPH with conditional homozygous deletion of the tumor suppressor gene, Stk11 (serine threonine kinase 11), in the Müllerian duct mesenchyme (MDM), which regresses in males during early fetal development. Cell lineage tracing studies confirmed that cells from the caudal MDM contribute to the stromal cell population of the dorsal periurethral area, which has been compared with the transition zone of the human prostate. These studies show that some of the stromal cells of the prostate are MD-derived, and that their mutation can lead to BPH.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1612284114

Authors: Jitu W. George, Amanda L. Patterson, Pradeep S. Tanwar, André Kajdacsy-Balla, Gail S. Prins, Jose M. Teixeira

Institutions: Michigan State University, University of Newcastle Australia, University of Illinois Chicago

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development