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The hope and the hype of organoid research

Year: 2017
Type: review
Abstract: The recent increase in organoid research has been met with great enthusiasm, as well as expectation, from the scientific community and the public alike. There is no doubt that this technology opens up a world of possibilities for scientific discovery in developmental biology as well as in translational research, but whether organoids can truly live up to this challenge is, for some, still an open question. In this Spotlight article, Meritxell Huch and Juergen Knoblich begin by discussing the exciting promise of organoid technology and give concrete examples of how this promise is starting to be realised. In the second part, Matthias Lutolf and Alfonso Martinez-Arias offer a careful and considered view of the state of the organoid field and its current limitations, and lay out the approach they feel is necessary to maximise the potential of organoid technology.
Source: Development
DOI: 10.1242/dev.150201
Institutions: Wellcome/MRC Cambridge Stem Cell Institute, University of Cambridge, Cancer Research UK, The Gurdon Institute, Wellcome Trust, Institute of Molecular Biotechnology, Austrian Academy of Sciences, École Polytechnique Fédérale de Lausanne
Language: English
Open Access status: green
Funders: Novartis Foundation, Wellcome Trust, Royal Society, National Centre for the Replacement, Refinement and Reduction of Animals in Research, École Polytechnique Fédérale de Lausanne, Österreichischen Akademie der Wissenschaften, Austrian Science Fund, Isaac Newton Trust, Horizon 2020 Framework Programme, Biotechnology and Biological Sciences Research Council, European Research Council, Seventh Framework Programme
Awards: G2393757400, Understanding the molecular mechanisms of adult liver regeneration., G3120014458, G3669042974, G3685823614, G7972619183
OpenAlex ID: W2597311576
FWCI: 2.844
Cites: 39
Cited by: 403
Related to: 10