Continuous Theta Burst Stimulation of the Lateral Cerebellum Decreases Cognitive Cerebello-Cerebral Functional Connectivity
Year: 2016
Type: dissertation
Abstract: Previous studies using continuous theta burst stimulation (cTBS) applied to Crus I of the lateral cerebellum have demonstrated an inhibition of the contralateral motor cortex and connections in the cerebello-thalamo-cortical (CTC) pathway. The aim of this thesis was to determine the effects of lateral cerebellar cTBS on cognitive and motor cerebello-cerebral networks using resting state functional magnetic resonance imaging (rsfMRI). Functional connectivity between four cerebello-cerebral seed pairs constituting the cognitive network [Crus I – Brodmann area (BA) 7, Crus I – BA8, Crus I – BA9, Crus I – BA39] and one cerebello-cerebral seed pair constituting the motor network (Lobule V hand area – BA4 hand area) were measured before and after cTBS in 12 healthy subjects. As hypothesized, lateral cerebellar cTBS induced a significant decrease in functional connectivity within the cognitive network, while motor functional connectivity remained unaltered. These results provide further insight into the effects of cerebellar cTBS at the network level.
Source: TSpace (University of Toronto)
Author: Anuj Rastogi
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2598104723