Year: 2006
Type: article
Abstract: Toll-like receptors (TLRs) are a family of proteins (e.g.TLR4) widely acknowledged as the body's first line of defense against invading microbes.TLR4 induction can take place both under pro-as well as pseudo-inflammatory stimuli.This TLR4 induction has been implicated in the genesis of inflammation, which subsequently can lead to the pathogenesis of atherosclerosis and autoimmune diseases.Investigating what brings about TLR4 expression during inflammation is of fundamental importance.Hence, we sought to determine the effects of cytokines on TLR4 expression in human endothelial cells.For the limited range of conditions tested, our studies suggest that TLR4 expression is unaffected when endothelial cells are treated with pro-inflammatory Lipopolysaccharide, Interferon beta and Interferon gamma.Further studies are needed to determine if these results are valid for a wider range of conditions.
Author: Harsh Pratap
Institution: Ohio University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2598157395