Year: 2014
Type: dissertation
Abstract: Epidemiological and experimental data suggest Type 1 Diabetes (T1D) and gut inflammatory disorders share genetic and environmental risk factors. Genetics and microbiome composition differentiate T1D-prone NOD mice and T1D-resistant NOR mice. In the first part of this study, we examined the possible protective effects of NOR-derived microbiome transplant in NOD mice. We report, despite quantifiable, durable changes in the gut microbiome of NOD recipients of NOR-derived microbiome transplant compared to NOD and NOR controls, these mice were not protected from T1D. Studies have also suggested that probiotic bacteria can have protective effects in T1D and gut inflammatory disorders. In the second part of this study, we examined the possible protective effects of treatment with probiotic microbes in the NOD mice. We report Protecflor probiotic-treated NOD mice showed quantifiable, durable changes in gut microbiome composition, and were protected from autoimmune infiltration of the islets compared to vehicle-treated controls.
Source: TSpace (University of Toronto)
Authors: Lam Yau, Christopher Yick
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2598432480