Work

Placental growth factor (PlGF) regulation and expression in endothelial cells

Year: 2016

Type: dissertation

Abstract: The role of Placenta growth factor (PlGF) in physiological angiogenesis is quiescent, preclinical and human studies have established PlGF angiogenic activity to be regulated in pathologies. PlGF elicits its cellular functions via (vascular endothelial growth factor receptor) VEGFR-1 alone, and has gained more attention for its safety profile, especially when compared to the risks involved in VEGF-derived therapies. Loss and gain studies of PlGF function highlight the contribution of PlGF in disease aggravation or alleviation; however, factors regulating PlGF expression remains elusive.

Source: University of Birmingham Institutional Research Archive (University of Birmingham)

Author: Niraja Padmalata Lal

Language: Dutch

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2598663776

Cites: 3

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Related to: 10