Higher Body Mass Index Is Associated With Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living With HIV
Year: 2017
Type: article
Study design: Observational Study
Abstract: BACKGROUND: A low proportion of CD28CD8 T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57CD28CD8 T cells among HIV-infected individuals on antiretroviral therapy is unknown. SETTING: In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8 T cell phenotypes: % CD28CD57CD8 T cells, % CD57 of CD28CD8 T cells, and % CD28 of all CD8 T cells. METHODS: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. RESULTS: Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m/kg). Greater BMI and waist circumference were both associated with higher % CD28CD57CD8 T cells and % CD57 of all CD28CD8 T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28 CD8 cells in fully adjusted models (0.078, 95% confidence interval: -0.053 to 0.209) was not significant. CONCLUSIONS: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28CD8 T cells and a greater proportion of CD57CD28 CD8 T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.
Authors: Michael J. A. Reid, Sanjiv M. Baxi, Lila A. Sheira, Alan L. Landay, Edward A. Frongillo, Adebola Adedimeji, Mardge H. Cohen, Eryka Wentz, Deborah R. Gustafson, Daniel Merenstein, Peter W. Hunt, Phyllis C. Tien, Sheri D. Weiser, for the Women's Interagency HIV Study (WIHS)
Institutions: University of California, San Francisco, San Francisco General Hospital, Rush University, University of South Carolina, Albert Einstein College of Medicine, John H. Stroger, Jr. Hospital of Cook County, Cook County Health and Hospitals System, Johns Hopkins University, State University of New York, SUNY Downstate Health Sciences University, Georgetown University, San Francisco VA Medical Center
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1089263533, G1344608833, Emory R38 Research Training Program, G2755707676, G3481933404, Miami Womens Interagency HIV Study WIHS, G4378641832, G4500389830, G483408255, Chicago WIHS Consortium V (CWC), G592158972, G65070246, G661928818, G669420692, University of North Carolina Womens Interagency HIV Study UNC WIHS, G773494495, G81379742, UAB-MISS WIHS Cohort, Emory Specialized Center of Research Excellence (SCORE) on Sex Differences, Extreme heat, pollution, wildfire smoke, and aging among people living with or at risk for HIV, G97119092, G986692823
OpenAlex ID: W2598777341