Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge
Year: 2017
Type: article
Study design: Observational Study
Abstract: Antibody-secreting cells are generated in regional lymphoid tissues and traffic as plasmablasts (PBs) via lymph and blood to target sites for local immunity. We used multiparameter flow cytometry to define PB trafficking programs (TPs, combinations of adhesion molecules and chemoattractant receptors) and their imprinting in patients in response to localized infection or immune insults. TPs enriched after infection or autoimmune inflammation of mucosae correlate with sites of immune response or symptoms, with different TPs imprinted during small intestinal, colon, throat, and upper respiratory immune challenge. PBs induced after intramuscular or intradermal influenza vaccination, including flu-specific antibody-secreting cells, display TPs characterized by the lack of mucosal homing receptors. PBs of healthy donors display diverse mucosa-associated TPs, consistent with homeostatic immune activity. Identification of TP signatures of PBs may facilitate noninvasive monitoring of organ-specific immune responses.
Source: JCI Insight
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,100
Awards: VIRAL GASTROENTERITIS--BASIS OF PROTECTION AND VIRULENCE, Mucosal and Systemic Immune Responses to Influenza Virus, Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune Profiling, G2869382552, Intestinal Lymphocyte Trafficking, Role and Regulation of colon Trafficking Novel G-Protein Coupled Receptors, Viral Gastroenteritis: Basis of Virulence and Protection, Vaccination and infection: indicators of immunological health and responsiveness, G73616645, CCR9 AND TECK IN INTESTINAL LYMPHOCYTE TRAFFICKING, Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B Cells, Viral Gastroenteritis: Basis of Protection and Virulence, G9000095646, G9000125282, Intestinal Lymphocyte Trafficking, Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro
OpenAlex ID: W2598981127