Year: 2017
Type: article
Abstract: Akhilesh Pandey Proteomics has already become firmly established for investigating puzzles in the field of biomedical research. In fact, it is now recognized as a key approach for what is increasingly being termed as “discovery science.” With the depth and coverage that one can achieve with mass spectrometry today, proteomics is all set to rival other more popular approaches such as genomics and transcriptomics. Almost every major biomedical research center boasts of some sort of a proteomics facility, at least in the developed world, which is a promising sign. It is also maturing as a field with standards being put in place for reporting and archiving of data, requirements for replicates and statistical analysis and increased use of high-resolution mass spectrometers. One aspect of proteomics that has lagged behind is translation into clinical practice. Given the complex and highly regulated nature of medicine, it is understandable that this aspect might take longer. Lately, there is a renewed thrust in the area of translational proteomics with more and more publications describing the use of proteomics for applications ranging from biomarkers to patient stratification. The goal of this special issue was to provide an overview of the advances in translational proteomics along with a sampling of the driving technologies as well as applications to medicine. In the Reviews section of this special issue, three reviews cover the role of kinase-targeted therapies, role of disulfides in disease and the use of proteomic profiling for cancer biomarker discovery. In the Technical Brief section, one paper discusses technologies that allow for robotic processing of samples for selected reaction monitoring (SRM) assays while the second one describes a superbinder SH2-domains for phosphotyrosine profiling. In the section on Driving Technologies for Translational Proteomics, four papers describe low-cost workflows, multiplexed approaches for MRM analysis of plasma or saliva and a novel approach for detecting cysteine-containing phosphopeptides. In the Cancer Signatures and Biomarkers section, five papers describe their findings from proteomic studies of several tumor types. In the Personalized Medicine section, five papers show how proteomics can be applied for a personalized approach for studying and treating disorders ranging from multiple sclerosis and allergic rhinitis to poor responders during in vitro fertilization. Finally, three papers under Biology and Disease describe the use of proteomics to study perturbed biological systems to understand different disorders. Akhilesh Pandey, M.D., Ph.D. Professor of Pathology, Oncology and Biological Chemistry McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University Baltimore, Maryland, USA
Source: PROTEOMICS
Author: Akhilesh Pandey
Institution: Johns Hopkins University
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2600167692