Work

TRIF as a Novel Modulator of Liver Inflammation and Fibrosis

Year: 2017

Type: editorial

Abstract: The central role of toll-like receptor 4 (TLR4) activation in nonalcoholic steatohepatitis (NASH) has been well-recognized, specifically its role in the activation of innate immune responses, hepatocyte apoptosis, and fibrosis. TLR4 could be activated by various signals; in the context of NASH dysregulation of gut microbial homeostasis, gut leakiness and consequent increase in bacteria-derived lipopolysaccharide (LPS) seem to play a major role. Activation of TLR4 involves adapter proteins including MyD88-adaptor-like and TRIF-related adaptor molecule (TRAM) recruiting Myd88 and TRIF, respectively, and ultimately leading to the activation of nuclear factor kappa B and/or interferon-regulatory factor 3 (IRF3).

Source: Cellular and Molecular Gastroenterology and Hepatology

DOI: 10.1016/j.jcmgh.2017.03.002

Author: Natalie J. Török

Institutions: University of California Davis Medical Center, University of California, Davis

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,430