Work

BMP-2-induced bone formation and neural inflammation

Year: 2017

Type: article

Abstract: Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation.

Source: Journal of Orthopaedics

DOI: 10.1016/j.jor.2017.03.003

Authors: Vi Nguyen, Carolyn A. Meyers, Noah Yan, Shailesh Agarwal, Benjamin Levi, Aaron W. James

Institutions: Johns Hopkins University, University of Michigan

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Musculoskeletal Transplant Foundation, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases