Year: 2003
Type: article
Abstract: Vestibular schwannomas continue to cause significant morbidity including hearing loss, facial nerve paralysis, brainstem compression and death.Although the gene responsible for maintaining tumor suppression in vestibular schwannomas has been identified, understanding of the mechanism of action of this Neurofibromatosis type 2 (NF2) gene has not yet been sufficient to allow application to clinical treatment.This dissertation presents three related investigations.The first is a characterization of the promoter sequence of the NF2 gene, which may be important both in mutation analysis and in tissue specific direction for modeling and treatments.The second investigation is the cDNA microarray analysis of expression of genes in vestibular schwannomas when compared to a normal nerve tissue.The third set of experiments examine one specific pathway, the retinoblastoma pathway, identified in the second investigation, and the role it plays in the development of vestibular schwannomas.The first experiment using NF2 promoter-luciferase constructs demonstrated both positive and negative regulatory elements in the 5' untranslated region of the DEDICATION This dissertation is dedicated to my wife Susan,
Author: Duane Bradley Welling
Institution: The Ohio State University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2600981501