Year: 2017
Type: preprint
Abstract: Animal models have played a pivotal role in all stages of vaccine development.Their predictive value for vaccine effectiveness depends on the pathogen, the robustness of the animal challenge model, and the correlates of protection (if known).This article will cover key questions regarding bridging animal studies to efficacy trials in humans.Examples include human papillomavirus (HPV) vaccine in which animal protection after vaccination with heterologous prototype virus-like particles (VLPs) predicted successful efficacy trials in humans, and a recent approval of anthrax vaccine in accordance with the "Animal Rule."The establishment of animal models predictive of vaccine effectiveness in humans has been fraught with difficulties with low success rate to date.Challenges facing the use of animal models for vaccine development against Ebola and HIV will be discussed. GREAT DEBATESWhat are the most interesting topics likely to come up over dinner or drinks with your colleagues?Or, more importantly, what are the topics that don't come up because they are a little too controversial?In Immune Memory and Vaccines: Great Debates, Editors Rafi Ahmed and Shane Crotty have put together a collection of articles on such questions, written by thought leaders in these fields, with the freedom to talk about the issues as they see fit.This short, innovative format aims to bring a fresh perspective by encouraging authors to be opinionated, focus on what is most interesting and current, and avoid restating introductory material covered in many other reviews.The Editors posed 13 interesting questions critical for our understanding of vaccines and immune memory to a broad group of experts in the field.In each case, several different perspectives are provided.Note that while each author knew that there were additional scientists addressing the same question, they did not know who these authors were, which ensured the independence of the opinions and perspectives expressed in each article.Our hope is that readers enjoy these articles and that they trigger many more conversations on these important topics.
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2601086746